Diabetic neuropathic pain(STZ-induced diabetes mellitus in rats)
Diabetic neuropathy is one of the representative complications of diabetes mellitus.
Because STZ-induced diabetes mellitus model in rats causes diabetic neuropathy, this model can be used to study diabetic neuropathic pain. Evaluation with Von Frey filament is the main method; besides, nerve conduction study can be used.
Von Frey test: Effects of Duloxetine and Pregabalin on STZ-induced diabetic neuropathic pain (DNP) in rats