Monocrotaline-induced pulmonary arterial hypertension in rats

Pulmonary arterial hypertension is caused by aggravation of blood flow in pulmonary artery that carries blood from the right ventricle to the lungs. Pulmonary arterial hypertension is induced in rats by administration of monocrotaline, and this is one of the most popular models. Right ventricular pressure and right ventricular weight are increased in the disease model, then these parameters are used for evaluation.